Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.35 |
| ▸ | TOP1 | P11387 | 2/20 | 0.35 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11932672 | 0.88 | MKNK1 (0.46) | MKNK1JAK2PIK3CAMAP4K4CLK2 | |
| SCHEMBL12722831 | 0.85 | MKNK1 (0.44) | MKNK1JAK2PIK3CAMAP4K4CLK2 | |
| SCHEMBL16543288 | 0.81 | MEN1 (0.37) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL16543278 | 0.81 | MEN1 (0.37) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL16543266 | 0.81 | MEN1 (0.37) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL16543272 | 0.81 | MEN1 (0.37) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL14803465 | 0.81 | MEN1 (0.37) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL14803614 | 0.80 | ALDH1A1 (0.39) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL14803837 | 0.79 | MEN1 (0.36) | MKNK1JAK2PIK3CAMAP4K4ALK | |
| SCHEMBL16543265 | 0.79 | MEN1 (0.36) | MKNK1JAK2PIK3CAMAP4K4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9353065-B2 | Heterocyclic bridged biphenyls | BASF SE (DE) | 2016-05-31 | — | — | US | disclosed |
| US-9353065-B2 | Heterocyclic bridged biphenyls | BASF SE (DE) | 2016-05-31 | — | — | US | disclosed |
| EP-2125752-B1 | HETEROCYCLIC BRIDGED BIPHENYLS | BASF SE (DE) | 2015-08-12 | — | — | EP | disclosed |
| US-20100109514-A1 | HETEROCYCLIC BRIDGED BIPHENYLS | UDC IRELAND LIMITED (IE) | 2010-05-06 | — | — | US | disclosed |
| US-20100109514-A1 | HETEROCYCLIC BRIDGED BIPHENYLS | UDC IRELAND LIMITED (IE) | 2010-05-06 | — | — | US | disclosed |
| WO-2008119666-A1 | HETEROCYCLIC BRIDGED BIPHENYLS | BASF SE (CH) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100109514-A1 | HETEROCYCLIC BRIDGED BIPHENYLS | OCIAD1, SBDS, OCIAD2 | MKNK1 4076/4885JAK2 4502/4885PIK3CA 1013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.