Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | GCK | P35557 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12695291 | 0.84 | ALDH1A1 (0.45) | ATRGSK3BDYRK1ASCN9AALDH1A1 | |
| SCHEMBL13563525 | 0.84 | GAA (0.49) | ATRGSK3BDYRK1ASCN9AALDH1A1 | |
| SCHEMBL12540480 | 0.83 | ATR (0.42) | ATRGSK3BDYRK1ASCN9AALDH1A1 | |
| SCHEMBL29272503 | 0.82 | BRAF (0.44) | ATRGSK3BDYRK1ASCN9AALDH1A1 | |
| SCHEMBL29465812 | 0.81 | KDM4D (0.47) | ATRGSK3BDYRK1AALDH1A1IRAK4 | |
| SCHEMBL2080457 | 0.81 | KDM4D (0.47) | ATRGSK3BDYRK1AALDH1A1IRAK4 | |
| SCHEMBL1192656 | 0.81 | ATR (0.50) | ATRGSK3BDYRK1ASCN9AGAA | |
| SCHEMBL828560 | 0.81 | TP53 (0.51) | ALDH1A1L3MBTL1 | |
| SCHEMBL30953487 | 0.81 | ATR (0.50) | ATRGSK3BDYRK1ASCN9AGAA | |
| SCHEMBL437390 | 0.79 | ATR (0.52) | ATRGSK3BDYRK1AIRAK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010067131-A1 | P38 MAP KINASE INHIBITORS | RESPIVERT LIMITED (GB) | 2010-06-17 | — | — | WO | disclosed |