Zardaverine

Zardaverine

SCHEMBL13334

COc1cc(-c2ccc(=O)[nH]n2)ccc1OC(F)F

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A P27815 6/20 1.00
PDE4B Q07343 6/20 1.00
PDE4C Q08493 6/20 1.00
PDE4D Q08499 6/20 1.00
PDE3B Q13370 6/20 1.00
PDE3A Q14432 6/20 1.00
LMNA P02545 3/20 1.00
CYP1A2 P05177 3/20 1.00
MAPK1 P28482 3/20 1.00
SMN1; SMN2 Q16637 3/20 1.00
CYP2C9 P11712 2/20 1.00
CYP2C19 P33261 2/20 1.00
TP53 P04637 1/20 1.00
HPGD P15428 1/20 1.00
TSHR P16473 1/20 1.00
BLM P54132 1/20 1.00
PMP22 Q01453 1/20 1.00
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
MAPT P10636 4/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Zardaverine SCHEMBL29388700 1.00 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPDE3B
Zardaverine SCHEMBL15263214 1.00 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL10779323 0.95 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL10764347 0.88 PDE4A (0.79) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL8479743 0.87 PDE4A (1.00) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL10758345 0.84 PDE4A (0.72) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL21969548 0.83 PDE3A (0.70) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL10761953 0.83 PDE4B (0.79) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL8635918 0.82 PDE4D (0.69) PDE4APDE4BPDE4CPDE4DPDE3B
SCHEMBL29892342 0.82 PDE4A (0.69) PDE4APDE4BPDE4CPDE4DPDE3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2206 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250319110-A1 SURFACE CALR CHEMICAL INDUCERS ZON LEONARD (US) 2025-10-16 US claimed
EP-4540374-A1 SURFACE CALR CHEMICAL INDUCERS The Children's Medical Center Corporation (US) 2025-04-23 EP claimed
EP-3334404-B1 COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A AND SLFN12 BROAD INST INC (US) 2024-09-18 EP claimed
US-11903992-B2 Composition comprising lidocaine, l-carnosine and dexpanthenol CELLIX BIO PRIVATE LIMITED (IN) 2024-02-20 US claimed
WO-2023244470-A1 SURFACE CALR CHEMICAL INDUCERS THE CHILDREN'S MEDICAL CENTER CORPORATION (US) 2023-12-21 WO claimed
WO-2023196821-A2 TARGETING NEUROPOD CELL GUCY2C TO CONTROL VISCERAL PAIN AND APPETITE THOMAS JEFFERSON UNIVERSITY (US) 2023-10-12 WO claimed
WO-2023196234-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-12 WO claimed
US-20230310380-A1 METHODS, DEVICES, AND SYSTEMS FOR TREATING LENS PROTEIN AGGREGATION DISEASES GLAZIER ALAN NEIL (US) 2023-10-05 US claimed
WO-2022190030-A1 A TOPICAL FORMULATION FOR THE TREATMENT OF SKIN DISEASES AVACA PHARMA PRIVATE LIMITED (IN) 2022-09-15 WO claimed
WO-2022157587-A1 A COMPOSITION COMPRISING LIDOCAINE, L-CARNOSINE AND DEXPANTHENOL CELLIX BIO PRIVATE LIMITED (IN) 2022-07-28 WO claimed
US-6156753-A Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction VIVUS, INC. (US) 2000-12-05 US claimed
WO-2000012076-A9 NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED INC (US) 2000-08-17 WO claimed
EP-1012188-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN, Wolf-Georg, Prof. Dr. (DE) 2000-06-28 EP claimed
WO-2000012076-A1 NITROSATED AND NITROSYLATED PHOSPHODIESTERASE INHIBITORS, COMPOSITIONS AND METHODS OF USE NITROMED, INC. (US) 2000-03-09 WO claimed
EP-0904266-A1 NITROSATED AND NITROSYLATED COMPOUNDS AND COMPOSITIONS AND THEIR USE FOR TREATING RESPIRATORY DISORDERS Nitromed, Inc. (US) 1999-03-31 EP claimed
WO-1999014239-A1 COMPOSITION FOR TREATING DIABETES MELLITUS AND OBESITY FORSSMANN WOLF GEORG (DE) 1999-03-25 WO claimed
WO-1997034871-A1 NITROSATED AND NITROSYLATED COMPOUNDS AND COMPOSITIONS AND THEIR USE FOR TREATING RESPIRATORY DISORDERS NITROMED, INC. (US) 1997-09-25 WO claimed
EP-0593567-B1 USE OF SUBSTITUTED PYRIDAZINES AGAINST DERMATOSIS BYK GULDEN LOMBERG CHEM FAB (DE) 1996-08-28 EP claimed
EP-0523513-A1 Use of substituted pyridazines for the treatment of dermatoses Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1993-01-20 EP claimed
US-4665074-A CARDIOTONIC, BRONCHOSPASMOLYTIC BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1987-05-12 US claimed