Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 6/20 | 1.00 |
| ▸ | PDE4C | Q08493 | 6/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 6/20 | 1.00 |
| ▸ | PDE3B | Q13370 | 6/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 6/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 3/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 3/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | HPGD | P15428 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | BLM | P54132 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zardaverine SCHEMBL13334 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| Zardaverine SCHEMBL15263214 | 1.00 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10779323 | 0.95 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10764347 | 0.88 | PDE4A (0.79) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8479743 | 0.87 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10758345 | 0.84 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL21969548 | 0.83 | PDE3A (0.70) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL10761953 | 0.83 | PDE4B (0.79) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL8635918 | 0.82 | PDE4D (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL29892342 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3334404-B1 | COMPOSITIONS AND METHODS FOR CANCER EXPRESSING PDE3A AND SLFN12 | BROAD INST INC (US) | 2024-09-18 | — | — | EP | claimed |
| EP-2704560-B1 | ORGAN CARE SOLUTION FOR EX-VIVO MACHINE PERFUSION OF DONOR LUNGS | TRANSMEDICS INC (US) | 2022-04-06 | — | — | EP | claimed |
| CN-114053280-A | Application of phosphodiesterase inhibitor or pharmaceutical composition thereof in preparation of medicine for treating novel coronavirus pneumonia | 南方科技大学 | 2022-02-18 | — | — | CN | claimed |
| WO-2022027180-A1 | APPLICATION OF PHOSPHODIESTERASE INHIBITOR OR PHARMACEUTICAL COMPOSITION THEREOF IN PREPARATION OF DRUG FOR TREATING NOVEL CORONAVIRUS PNEUMONIA | 南方科技大学 | 2022-02-10 | — | — | WO | claimed |
| CN-119012999-A | Improved nasal administration of pharmaceutical formulations | 思瑞诺医疗有限公司 | 2024-11-22 | — | — | CN | disclosed |
| CN-118871101-A | Improved nasal administration of parkinson's disease therapeutic agents | 思瑞诺医疗有限公司 | 2024-10-29 | — | — | CN | disclosed |
| CN-118715013-A | Nasal spray for phosphodiesterase inhibitors | 思瑞诺医疗有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-118159644-A | Method for producing enteroendocrine cells, enteroendocrine cells derived from pluripotent stem cells, medium or medium kit, and use thereof | 富士胶片株式会社 | 2024-06-07 | — | — | CN | disclosed |
| CN-113473993-B | Methods and compositions for treating motor neuron diseases | 巴伦西亚大学 | 2024-06-04 | — | — | CN | disclosed |
| CN-111684058-B | Method for inducing differentiation from pluripotent stem cells into intestinal epithelial cells | 公立大学法人名古屋市立大学 | 2023-07-28 | — | — | CN | disclosed |
| US-20220347170-A1 | Method of Reducing Brow Ache | LENZ THERAPEUTICS OPERATIONS, INC. | 2022-11-03 | — | — | US | disclosed |
| WO-2022232205-A1 | A METHOD OF REDUCING BROW ACHE | LENZ THERAPEUTICS, INC. (US) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022148418-A1 | PHARMACEUTICAL COMPOSITION CAPABLE OF BEING DELIVERED BY METERED DOSE INHALER | 江苏恒瑞医药股份有限公司 | 2022-07-14 | — | — | WO | disclosed |
| CN-114699528-A | Compositions and methods for PDE3A or SLFN12 expressing cancers | 布罗德研究所股份有限公司 | 2022-07-05 | — | — | CN | disclosed |
| CN-108366947-B | Compositions and methods for PDE3A or SLFN12 expressing cancers | 布罗德研究所股份有限公司 | 2022-03-29 | — | — | CN | disclosed |
| CN-114053280-A | Application of phosphodiesterase inhibitor or pharmaceutical composition thereof in preparation of medicine for treating novel coronavirus pneumonia | 南方科技大学 | 2022-02-18 | — | — | CN | disclosed |
| CN-114053280-A | Application of phosphodiesterase inhibitor or pharmaceutical composition thereof in preparation of medicine for treating novel coronavirus pneumonia | 南方科技大学 | 2022-02-18 | — | — | CN | disclosed |
| WO-2022027180-A1 | APPLICATION OF PHOSPHODIESTERASE INHIBITOR OR PHARMACEUTICAL COMPOSITION THEREOF IN PREPARATION OF DRUG FOR TREATING NOVEL CORONAVIRUS PNEUMONIA | 南方科技大学 | 2022-02-10 | — | — | WO | disclosed |