Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.69 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.69 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.69 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.69 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.69 |
| ▸ | HPGD | P15428 | 3/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | TP53 | P04637 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.69 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19283081 | 1.00 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL19283074 | 0.90 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Zardaverine SCHEMBL15263214 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Zardaverine SCHEMBL29388700 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| Zardaverine SCHEMBL13334 | 0.82 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL19283072 | 0.80 | MAPK1 (0.41) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL14910704 | 0.78 | PDE4D (0.67) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL10779323 | 0.77 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL1769751 | 0.73 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 | |
| SCHEMBL23409918 | 0.73 | PDE4D (0.48) | PDE4APDE4BPDE4CPDE4DSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114945368-B | N2-arylmethyl-4-haloalkyl-pyridazin-3-one compounds and uses thereof | 香槟-阿尔登兰斯大学 | 2025-01-10 | — | — | CN | disclosed |
| CN-114945368-A | N2-arylmethyl-4-haloalkyl-pyridazin-3-one compounds and uses thereof | 香槟-阿尔登兰斯大学 | 2022-08-26 | — | — | CN | disclosed |