Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PGR | P06401 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 4/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376339 | 0.90 | PTGES (0.58) | NR3C1PTGESALOX5SMN1; SMN2PTPN22 | |
| SCHEMBL3379996 | 0.88 | NR3C1 (0.58) | NR3C1PTGESALOX5SMN1; SMN2PGR | |
| SCHEMBL13337354 | 0.85 | SMN1; SMN2 (0.51) | NR3C1SMN1; SMN2LMNAALDH1A1NPSR1 | |
| SCHEMBL3376558 | 0.85 | PTGES (0.46) | NR3C1PTGESALOX5SMN1; SMN2LMNA | |
| SCHEMBL3377815 | 0.84 | PTGES (0.52) | NR3C1PTGESALOX5SMN1; SMN2PGR | |
| SCHEMBL3377212 | 0.82 | SMN1; SMN2 (0.71) | SMN1; SMN2LMNAALDH1A1NPSR1MMP2 | |
| SCHEMBL3376552 | 0.78 | NR3C1 (0.48) | NR3C1PTGESALOX5SMN1; SMN2PGR | |
| SCHEMBL3376989 | 0.77 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAALDH1A1NPSR1MMP2 | |
| SCHEMBL3374754 | 0.76 | MCL1 (0.51) | NR3C1PTGESALOX5SMN1; SMN2PGR | |
| SCHEMBL3374719 | 0.74 | NR3C1 (0.42) | NR3C1PTGESALOX5SMN1; SMN2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113449-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113449-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNJ2, HCN4, KCNH2 | NR3C1 2869/4885PTGES 668/4885ALOX5 1350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.