Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22357458 | 0.92 | POLB (0.61) | POLBHDAC1TAAR1MAPTMEN1 | |
| SCHEMBL13246544 | 0.81 | MAPT (0.62) | POLBTAAR1MAPTMEN1KMT2A | |
| SCHEMBL10942647 | 0.79 | POLB (0.67) | POLBTAAR1MAPTMEN1KMT2A | |
| SCHEMBL11251550 | 0.79 | GAA (0.64) | POLBHDAC1TAAR1MAPTMEN1 | |
| SCHEMBL29445584 | 0.78 | ALDH1A1 (0.59) | POLBTAAR1MAPTMEN1KMT2A | |
| SCHEMBL10368145 | 0.78 | POLB (0.59) | POLBHDAC1TAAR1MAPTMEN1 | |
| SCHEMBL4741417 | 0.76 | TAAR1 (0.79) | POLBTAAR1MAPTMEN1KMT2A | |
| SCHEMBL8786423 | 0.76 | POLB (0.57) | POLBHDAC1TAAR1MAPTMEN1 | |
| SCHEMBL5960486 | 0.76 | TAAR1 (0.79) | POLBTAAR1MAPTMEN1KMT2A | |
| SCHEMBL1802214 | 0.76 | TAAR1 (0.79) | POLBTAAR1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015126930-A2 | BOOSTER DRUG THERAPY FOR MYCOBACTERIUM INFECTIONS | STC.UNM (US) | 2015-08-27 | — | — | WO | disclosed |
| US-7732490-B2 | Methods of treating cancer | MERCK HDAC RESEARCH, LLC (US) | 2010-06-08 | — | — | US | disclosed |
| US-7652069-B2 | Polymorphs of suberoylanilide hydroxamic acid | MERCK HDAC RESEARCH, LLC (US) | 2010-01-26 | — | — | US | disclosed |
| US-20080194692-A1 | Polymorphs of suberoylanilide hydroxamic acid | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-08-14 | — | — | US | disclosed |
| US-20080119562-A1 | Methods of Inducing Terminal Differentiation | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-05-22 | — | — | US | disclosed |
| US-20080114069-A1 | Methods of inducing terminal differentiation | RICHON VICTORIA M | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080119562-A1 | Methods of Inducing Terminal Differentiation | HDAC3, HDAC1, HDAC5 | POLB 991/4885HDAC1 2/4885TAAR1 3927/4885 |
| US-20080194692-A1 | Polymorphs of suberoylanilide hydroxamic acid | HDAC1, HDAC4, HDAC5 | POLB 860/4885HDAC1 1/4885TAAR1 4646/4885 |
| US-20080114069-A1 | Methods of inducing terminal differentiation | HDAC3, HDAC1, HDAC5 | POLB 991/4885HDAC1 2/4885TAAR1 3927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.