Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.46 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.42 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497244 | 0.84 | RPS6KB1 (0.49) | RPS6KB1TRPM8JAK3ALDH1A1 | |
| SCHEMBL2479832 | 0.78 | RPS6KB1 (0.61) | MAPK8AURKARPS6KB1AURKBJAK3 | |
| SCHEMBL28191670 | 0.70 | TRPM8 (0.44) | TRPM8MAOBEPHX1ALDH1A1 | |
| SCHEMBL29693639 | 0.70 | EPHX1 (0.51) | MAPK8TRPM8MAOBEPHX1ALDH1A1 | |
| SCHEMBL22261203 | 0.70 | JAK3 (0.61) | SYKCAMK1DAURKARPS6KB1AURKB | |
| SCHEMBL30254925 | 0.68 | ICAM1 (0.52) | SYKKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL29006543 | 0.68 | ICAM1 (0.52) | SYKKCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL22261134 | 0.68 | JAK3 (0.62) | SYKCAMK1DAURKARPS6KB1AURKB | |
| SCHEMBL31023529 | 0.68 | POLB (0.57) | — | |
| SCHEMBL6410982 | 0.68 | HDAC6 (0.56) | MAOBEPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010061971-A1 | PYRIDINE-3-CARBOXYAMIDE DERIVATIVE | 興和株式会社 (JP) | 2010-06-03 | — | — | WO | disclosed |