Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PGK1 | P00558 | 2/20 | 0.36 |
| ▸ | PGK2 | P07205 | 2/20 | 0.36 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.35 |
| ▸ | ACP3 | P15309 | 4/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | FABP7 | O15540 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA5A | P35218 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13337650 | 0.77 | NPSR1 (0.48) | ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL13337687 | 0.75 | PTPN1 (0.47) | PTPN1ALDH1A1TSHRPGK1PGK2 | |
| SCHEMBL13337665 | 0.74 | MEN1 (0.55) | ALDH1A1CA2 | |
| SCHEMBL777165 | 0.73 | MEN1 (0.53) | PTPN1ALDH1A1TSHRHTTSMN1; SMN2 | |
| SCHEMBL4134585 | 0.73 | TDP1 (0.45) | PTPN1ALDH1A1TSHRHTTSMN1; SMN2 | |
| SCHEMBL13337653 | 0.73 | CA12 (0.40) | PTPN1ALDH1A1TSHRCA1CA2 | |
| SCHEMBL13337684 | 0.71 | CYP3A4 (0.44) | — | |
| SCHEMBL24072545 | 0.70 | SMN1; SMN2 (0.49) | ALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL781336 | 0.70 | CA2 (0.44) | ALDH1A1TSHRHTTSMN1; SMN2CA2 | |
| SCHEMBL17169192 | 0.70 | DGAT1 (0.49) | PTPN1ALDH1A1TSHRHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709465-B2 | Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709465-B2 | Phosphorous containing compounds including triphenylmethylphosphonate esters for the treatment of melanoma and other cancers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2010-05-04 | — | — | US | disclosed |
| US-20090004293-A1 | Phosphorous Containing Compounds Including Triphenylmethylphosphonate Esters for the Treatment of Melanoma and Other Cancers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-01 | — | — | US | disclosed |
| US-20090004293-A1 | Phosphorous Containing Compounds Including Triphenylmethylphosphonate Esters for the Treatment of Melanoma and Other Cancers | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2009-01-01 | — | — | US | disclosed |
| WO-2007137200-A2 | PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2007-11-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004293-A1 | Phosphorous Containing Compounds Including Triphenylmethylphosphonate Esters for the Treatment of Melanoma and Other Cancers | PHOSPHO1, MCL1, MTMR1 | PTPN1 374/4885ALDH1A1 3084/4885TSHR 3271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.