Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GSR | P00390 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011707 | 1.00 | MAPT (0.43) | MAPTTP53GSRGAATDP1 | |
| SCHEMBL2012775 | 0.82 | MAPT (0.48) | MAPTTP53GAA | |
| SCHEMBL638385 | 0.81 | CHRNB2 (0.43) | MAPTTP53GSRTDP1CHRNB2 | |
| SCHEMBL637878 | 0.81 | CHRNB2 (0.43) | MAPTTP53GSRTDP1CHRNB2 | |
| SCHEMBL9238948 | 0.81 | GSR (0.35) | MAPTGSR | |
| SCHEMBL2012744 | 0.80 | SMN1; SMN2 (0.37) | MAPTTP53GSRTDP1SMN1; SMN2 | |
| SCHEMBL23927596 | 0.79 | GSR (0.42) | MAPTGSRTDP1POLB | |
| SCHEMBL2012678 | 0.79 | GSR (0.42) | MAPTGSRTDP1POLB | |
| SCHEMBL17674083 | 0.77 | MAPT (0.45) | MAPTTP53GAATDP1SMN1; SMN2 | |
| SCHEMBL8957333 | 0.77 | GSR (0.50) | MAPTGSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010062415-A1 | NITROOXY CYCLOALKANE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2010-06-03 | — | — | WO | disclosed |