SCHEMBL1334130

SCHEMBL1334130

COc1ccc(C2(c3ccc(OC)cc3)C=Cc3c(C(=O)OCCOCCO)c(-c4ccccc4)c4ccccc4c3O2)cc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.35
NPC1 O15118 1/20 0.35
ATM Q13315 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
TP53 P04637 2/20 0.35
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
PADI4 Q9UM07 4/20 0.34
MAPT P10636 1/20 0.33
GPR84 Q9NQS5 1/20 0.33
CHRM5 P08912 2/20 0.33
CHRM1 P11229 2/20 0.33
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM3 P20309 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
EDNRA P25101 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1332545 1.00 L3MBTL1 (0.35) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL29565409 1.00 L3MBTL1 (0.35) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL29565416 1.00 L3MBTL1 (0.35) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL29565436 1.00 L3MBTL1 (0.35) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL1332475 1.00 L3MBTL1 (0.35) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL29565745 0.95 L3MBTL1 (0.37) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL1332905 0.95 L3MBTL1 (0.37) L3MBTL1NPC1ATMSMN1; SMN2TP53
SCHEMBL23800877 0.92 LMNA (0.34) NPC1SMN1; SMN2TP53KDM4EALDH1A1
SCHEMBL30175143 0.92 LMNA (0.34) NPC1SMN1; SMN2TP53KDM4EALDH1A1
SCHEMBL1332535 0.92 KDM4E (0.35) L3MBTL1NPC1ATMSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12285922-B2 Method for making photofunctional contact lenses ALCON INC. (CH) 2025-04-29 US claimed
EP-4313567-B1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC (CH) 2025-01-29 EP claimed
US-12111443-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2024-10-08 US claimed
US-11945895-B2 Photochromic polydiorganosiloxane vinylic crosslinkers ALCON INC. (CH) 2024-04-02 US claimed
CN-115605529-B Photochromic polydiorganosiloxane vinyl cross-linking agent 爱尔康公司 2024-03-26 CN claimed
EP-4118134-B1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2024-02-28 EP claimed
EP-4313567-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-02-07 EP claimed
EP-4304843-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES Alcon Inc. (CH) 2024-01-17 EP claimed
US-11833771-B2 Method for making photochromic contact lenses ALCON INC. (CH) 2023-12-05 US claimed
EP-4118134-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS Alcon Inc. (CH) 2023-01-18 EP claimed
US-20220283338-A1 METHOD FOR MAKING PHOTOCHROMIC CONTACT LENSES ALCON INC. (CH) 2022-09-08 US claimed
US-20210284806-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 US claimed
WO-2021181307-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
US-20210284778-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC (CH) 2021-09-16 US claimed
WO-2021181341-A1 PHOTOCHROMIC POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS ALCON INC. (CH) 2021-09-16 WO claimed
EP-1776436-B1 PHOTOCHROMIC MATERIALS TRANSITIONS OPTICAL INC (US) 2019-05-08 EP claimed
US-7465415-B2 Photochromic materials derived from ring-opening monomers and photochromic initiators PPG INDUSTRIES OHIO, INC. (US) 2008-12-16 US claimed
US-20060022176-A1 Reaction product of a ring-opening cyclic ester or carbonate and a photochromic initiator, especially a naphtho[1,2-b]quinone with one or more hydroxy groups, e.g., (1) 3,3-di(4-methoxyphenyl)-6,7-dimethoxy-13-methyl-13-(2-(2-hydroxyethoxy)ethoxy)-3H,13H-indeno[2,1-f]naphtho[1,2-b]pyran. TRANSITIONS OPTICAL LIMITED (IE) 2006-02-02 US claimed
EP-1112263-B1 POLYMERIZABLE POLYALKOXYLATED NAPHTHOPYRANS TRANSITIONS OPTICAL INC (US) 2005-06-08 EP claimed
US-6113814-A PHOTOCHROMIC; END-CAPPED WITH A POLYMERIZABLE GROUP. TRANSITIONS OPTICAL, INC. (US) 2000-09-05 US claimed