Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.68 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.52 |
| ▸ | NQO1 | P15559 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13343316 | 0.84 | ABCG2 (0.59) | ABCG2ALDH1A1APPMAPTKMT2A | |
| SCHEMBL18099393 | 0.80 | MEN1 (0.74) | TNFRSF1AABCG2ALDH1A1MAPTKMT2A | |
| SCHEMBL9717780 | 0.80 | MEN1 (0.74) | TNFRSF1AABCG2ALDH1A1MAPTKMT2A | |
| SCHEMBL9548241 | 0.78 | MAPT (0.60) | ALDH1A1APPMAPTKMT2ACYP3A4 | |
| SCHEMBL9548237 | 0.78 | MAPT (0.60) | ALDH1A1APPMAPTKMT2ACYP3A4 | |
| SCHEMBL3173746 | 0.75 | TNFRSF1A (0.72) | TNFRSF1AABCG2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL3173761 | 0.75 | TNFRSF1A (0.72) | TNFRSF1AABCG2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL998114 | 0.75 | ABCG2 (0.65) | TNFRSF1AABCG2ALDH1A1APPMAPT | |
| SCHEMBL998110 | 0.75 | ABCG2 (0.65) | TNFRSF1AABCG2ALDH1A1APPMAPT | |
| SCHEMBL3220601 | 0.74 | MAPT (1.00) | ABCG2ALDH1A1MAPK1APPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709526-B2 | Use of cyclolignans and new cyclolignans | BIOVITRUM AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-7709526-B2 | Use of cyclolignans and new cyclolignans | BIOVITRUM AB (SE) | 2010-05-04 | — | — | US | disclosed |