Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.72 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | NQO1 | P15559 | 1/20 | 0.65 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.64 |
| ▸ | KRAS | P01116 | 4/20 | 0.63 |
| ▸ | CA1 | P00915 | 3/20 | 0.63 |
| ▸ | CA2 | P00918 | 3/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MAOA | P21397 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18099393 | 1.00 | MEN1 (0.74) | MEN1KMT2APOLBTNFRSF1AABCG2 | |
| SCHEMBL30307328 | 0.93 | RAB9A (0.71) | MEN1KMT2APOLBTNFRSF1AABCG2 | |
| SCHEMBL3173746 | 0.88 | TNFRSF1A (0.72) | TNFRSF1AABCG2MAPTALDH1A1KDM4E | |
| SCHEMBL28549138 | 0.88 | ABCG2 (0.71) | MEN1KMT2APOLBTNFRSF1AABCG2 | |
| SCHEMBL3173761 | 0.88 | TNFRSF1A (0.72) | TNFRSF1AABCG2MAPTALDH1A1KDM4E | |
| SCHEMBL25257640 | 0.83 | NPC1 (0.87) | MEN1KMT2APOLBTNFRSF1ANPC1 | |
| SCHEMBL11959782 | 0.83 | ABCG2 (0.72) | MEN1KMT2APOLBTNFRSF1AABCG2 | |
| SCHEMBL998114 | 0.82 | ABCG2 (0.65) | MEN1KMT2APOLBTNFRSF1AABCG2 | |
| SCHEMBL28549137 | 0.82 | RAB9A (0.73) | MEN1KMT2APOLBTNFRSF1AABCG2 | |
| SCHEMBL998110 | 0.82 | ABCG2 (0.65) | MEN1KMT2APOLBTNFRSF1AABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112770755-A | Compositions, syntheses, preparations and uses of analogs derived from position 7 and 9 of platform drug FL118 for treating human diseases | 坎格特生物技术制药有限责任公司 | 2021-05-07 | — | — | CN | disclosed |
| US-5120862-A | Cyclization with lewis acid in presence of acid anhydride catalyst | BRISTOL-MYERS COMPANY (US) | 1992-06-09 | — | — | US | disclosed |
| US-5086182-A | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof | BRISTOL-MYERS COMPANY (US) | 1992-02-04 | — | — | US | disclosed |
| US-5011948-A | Cleavage of isoxazole rings, reduction to amine, cyclization, lactonization; anticarcinogenic agents | BRISTOL-MYERS COMPANY (US) | 1991-04-30 | — | — | US | disclosed |
| US-4866189-A | ANTITUMOR, ANTICANCER AGENT | BRISTOL-MYERS COMPANY (US) | 1989-09-12 | — | — | US | disclosed |
| US-4795819-A | ANTITUMOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1989-01-03 | — | — | US | disclosed |
| US-4728740-A | ANTINEOPLASTIC | BRISTOL-MYERS COMPANY (US) | 1988-03-01 | — | — | US | disclosed |
| US-4644072-A | ANTITUMOR AGENTS | BRISTOL-MYERS COMPANY (US) | 1987-02-17 | — | — | US | disclosed |