Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2659689 | 0.84 | HPGDS (0.57) | — | |
| SCHEMBL21679451 | 0.82 | APP (0.58) | KDM4EAPPHPGDALDH1A1CYP1A2 | |
| SCHEMBL29869041 | 0.82 | APP (0.58) | KDM4EAPPHPGDALDH1A1CYP1A2 | |
| SCHEMBL3250837 | 0.81 | NQO1 (0.43) | KDM4EAPPHPGDALDH1A1MAPT | |
| SCHEMBL2252968 | 0.80 | APP (0.62) | APPHPGDPOLBMAPTMEN1 | |
| SCHEMBL2662882 | 0.76 | HSD17B10 (0.58) | KDM4EHPGDALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL11199460 | 0.73 | KDM4E (0.64) | KDM4EHPGDALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL10069794 | 0.73 | APP (0.84) | APPPOLBMEN1KMT2ANPC1 | |
| SCHEMBL17858186 | 0.72 | APP (0.63) | APPSMN1; SMN2 | |
| SCHEMBL10309631 | 0.71 | MEN1 (0.70) | KDM4EHPGDCYP1A2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709658-B2 | Process for synthesizing a substituted pyrazole | MERCK SHARP & DOHME CORP. (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709658-B2 | Process for synthesizing a substituted pyrazole | MERCK SHARP & DOHME CORP. (US) | 2010-05-04 | — | — | US | disclosed |
| US-20090054662-A1 | Process for synthesizing a substituted pyrazole | MERCK SHARP & DOHME LLC | 2009-02-26 | — | — | US | disclosed |
| US-20090054662-A1 | Process for synthesizing a substituted pyrazole | MERCK SHARP & DOHME LLC | 2009-02-26 | — | — | US | disclosed |
| WO-2007015999-A2 | PROCESS FOR SYNTHESIZING A SUBSTITUTED PYRAZOLE | MERCK & CO., INC. (US) | 2007-02-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054662-A1 | Process for synthesizing a substituted pyrazole | GLP1R, GCGR, GIPR | KDM4E 2966/4885APP 1781/4885HPGD 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.