Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.44 |
| ▸ | HTR7 | P34969 | 10/20 | 0.43 |
| ▸ | HTR6 | P50406 | 9/20 | 0.43 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | HTR2B | P41595 | 8/20 | 0.43 |
| ▸ | HTR1D | P28221 | 4/20 | 0.43 |
| ▸ | HTR1B | P28222 | 4/20 | 0.43 |
| ▸ | HTR5A | P47898 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 4/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8226241 | 0.80 | NOTUM (0.56) | HTR7HTR6HTR1AHTR2BHTR1D | |
| SCHEMBL8226159 | 0.78 | HTR7 (0.43) | HTR7HTR6HTR1AHTR2BHTR1D | |
| SCHEMBL8221004 | 0.76 | KMT2A (0.48) | HTR7HTR6HTR1AHTR2BHTR1D | |
| SCHEMBL8228663 | 0.75 | KCNH2 (0.44) | TTRHTR7HTR6ADRB1ADRB2 | |
| SCHEMBL8415635 | 0.75 | AXL (0.41) | — | |
| SCHEMBL6194571 | 0.75 | HTR1A (0.58) | HTR7HTR6HTR1AHTR2BHTR1B | |
| SCHEMBL4909469 | 0.74 | HTR7 (0.58) | HTR7HTR6HTR1AHTR2BHTR1D | |
| SCHEMBL8229627 | 0.74 | MAPT (0.47) | TTRHTR7HTR6HTR1AHTR2B | |
| SCHEMBL8226475 | 0.73 | HTR7 (0.43) | HTR7HTR6HTR1AHTR2BOPRL1 | |
| SCHEMBL8226105 | 0.73 | HTR7 (0.40) | TTRHTR7HTR6HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7709492-B2 | Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-05-04 | — | — | US | disclosed |
| US-7709492-B2 | Pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2010-05-04 | — | — | US | disclosed |
| US-7465740-B2 | 2-heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2008-12-16 | — | — | US | disclosed |
| US-7465740-B2 | 2-heteroaryl-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidine adenosine A2a receptor antagonists | SCHERING CORPORATION (US) | 2008-12-16 | — | — | US | disclosed |