Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | INSR | P06213 | 1/20 | 0.31 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522167 | 0.72 | — | — | |
| SCHEMBL18077275 | 0.72 | HDAC1 (0.31) | — | |
| SCHEMBL19221920 | 0.69 | EGFR (0.42) | JAK2INSRPTK2ALK | |
| SCHEMBL24197738 | 0.69 | JAK2 (0.32) | JAK2INSRPTK2ALKALDH1A1 | |
| SCHEMBL25469001 | 0.69 | PDE4B (0.35) | JAK2 | |
| SCHEMBL24197995 | 0.66 | PDE4B (0.35) | JAK2INSRPTK2ALK | |
| SCHEMBL322342 | 0.62 | — | — | |
| SCHEMBL1942840 | 0.61 | GABRG2 (0.35) | DYRK1BALDH1A1 | |
| SCHEMBL997839 | 0.58 | FTO (0.50) | DYRK1BINSRALDH1A1CYP1A2CLK4 | |
| SCHEMBL15973521 | 0.57 | DYRK1A (0.51) | DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |