Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | AKR1B10 | O60218 | 4/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13347303 | 0.94 | CYP3A4 (0.51) | TRPM8ALOX5NPC1CASP3RAB9A | |
| SCHEMBL13347146 | 0.89 | KDM4E (0.52) | TTRCYP3A4CYP1A2KDM4EALDH1A1 | |
| SCHEMBL3127872 | 0.85 | PLA2G4A (0.57) | CYP3A4CYP1A2KDM4EALDH1A1LMNA | |
| SCHEMBL3127861 | 0.85 | PLA2G4A (0.57) | CYP3A4CYP1A2KDM4EALDH1A1LMNA | |
| SCHEMBL3126855 | 0.79 | SMN1; SMN2 (0.59) | TRPM8CYP3A4CYP1A2MAPK1SMN1; SMN2 | |
| SCHEMBL3120694 | 0.79 | PLA2G4A (0.49) | CYP3A4CYP1A2KDM4ELMNATP53 | |
| SCHEMBL3120684 | 0.79 | PLA2G4A (0.49) | CYP3A4CYP1A2KDM4ELMNATP53 | |
| SCHEMBL7714738 | 0.77 | MEN1 (0.47) | TTRCYP3A4AKR1B10AKR1B1CYP1A2 | |
| SCHEMBL27371971 | 0.75 | TTR (0.62) | ALOX5NPC1CASP3RAB9ASENP8 | |
| SCHEMBL3126985 | 0.73 | SMN1; SMN2 (0.63) | TRPM8ALOX5CYP3A4CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293781-B2 | Indole derivatives having cPLA2 inhibiting activity and applications and production methods of the same | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2012-10-23 | — | — | US | disclosed |
| US-20100113777-A1 | INDOLE DERIVATIVES HAVING cPLA2 INHIBITING ACTIVITY AND APPLICATIONS AND PRODUCTION METHODS OF THE SAME | ASUBIO PHARMA CO., LTD. (JP) | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113777-A1 | INDOLE DERIVATIVES HAVING cPLA2 INHIBITING ACTIVITY AND APPLICATIONS AND PRODUCTION METHODS OF THE SAME | PLA2G4A, PLA2G2E, PLA2G6 | TRPM8 1123/4885ALOX5 27/4885NPC1 1359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.