PLA2G6

85/88 kDa calcium-independent phospholipase A2 · O60733 · PLA2G6 on Sugi Atlas →

4,126 patent compounds predicted against PLA2G6, 2,305 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Bromoenol Lactone (SCHEMBL2060001)	1.00	4/20
Bromoenol Lactone (SCHEMBL2060073)	1.00	4/20
Bromoenol Lactone (SCHEMBL2060074)	1.00	4/20
SCHEMBL3296491	1.00	4/20
SCHEMBL3296494	1.00	4/20
SCHEMBL3296498	1.00	4/20
(S)-Bromoenol Lactone (SCHEMBL3298296)	1.00	4/20
Bromoenol Lactone (SCHEMBL3302140)	1.00	4/20
Bromoenol Lactone (SCHEMBL3302144)	1.00	4/20
SCHEMBL2433362	0.54	4/20
SCHEMBL2433365	0.54	4/20
SCHEMBL2433366	0.54	4/20
SCHEMBL2423747	0.51	4/20
SCHEMBL2423749	0.51	4/20
SCHEMBL4802338	0.50	4/20
SCHEMBL4800917	0.49	4/20
SCHEMBL2083374	0.49	4/20
SCHEMBL576000	0.46	4/20
SCHEMBL657069	0.44	4/20
SCHEMBL576081	0.44	4/20

Clinical trials — most relevant to PLA2G6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comparison of Simvastatin Versus Simvastatin/Ezetimibe on Small Dense Low -Density Lipoprotein (LDL)	PHASE4	COMPLETED
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study	PHASE4	COMPLETED
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients	PHASE4	COMPLETED
A Randomized Controlled Pilot Trial of Indomethacin in Acute Pancreatitis	PHASE3	COMPLETED
Montelukast in Parkinson Disease	PHASE2/PHASE3	RECRUITING
Aspirin and Renal Disease Progression in Patients With Type 2 Diabetes	PHASE3	UNKNOWN
Lovaza's Effect on the Activation of Platelets	PHASE2	COMPLETED
Effect of Gemfibrozil on Serum Glycosylphosphatidylinositol (GPI) Phospholipase D and Triglycerides	PHASE1	COMPLETED
Assessment of Coronary Plaque Composition Using Optical Coherence Tomography	PHASE1	COMPLETED
Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.	nan	COMPLETED
Plasma Free Fatty Acids Profile As A Diagnostic Tool For Acute Ischemic Stroke	nan	COMPLETED
Positron Emission Tomography (PET) to Study Brain Signaling	nan	COMPLETED
EPICO: (Study for the Pro-resolution of Chronic Inflammation in Obesity. Original Acronym From Spanish)	nan	UNKNOWN
PET Imaging of DHA Metabolism	nan	COMPLETED
Mucomyst for Hepatitis C	nan	SUSPENDED
Molecular Markers of Human Sperm Function	nan	WITHDRAWN
Lipoprotein-associated Phospholipase A2 in Patients With Type 2 Diabetes	nan	COMPLETED
LDL-Apheresis for FSGS CardioRenal Outcomes	nan	COMPLETED
Autotaxin (ATX) as a Marker for Breast Cancer	nan	UNKNOWN
Characterization of New Candidate Genes in Cases of Human Inherited Thrombocytopenia (CATCH)	nan	COMPLETED
The Contribution of Lp-PLA2 Level to the Presence of Coronary Plaques in Patients With Non Alcoholic Fatty Liver Disease	nan	UNKNOWN
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
Computed Tomography and Biomarker Analysis in Diagnosing Coronary Artery Disease in Asymptomatic Patients Who Have Undergone Stem Cell Transplant	nan	COMPLETED
Candida Associated Cytokines in Oral Leukoplakia	nan	COMPLETED
The Association Between Post-ERCP Acute Pancreatitis and Various Genetic Mutations	nan	COMPLETED
the Role of plin5 in the Development of Nonalcoholic Fatty Liver Disease.	nan	UNKNOWN
Lp-PLA2 and Coronary Atherosclerosis in Humans	nan	COMPLETED
Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center	nan	COMPLETED
Collaborative Studies on the Genetics of Asthma (CSGA)	nan	COMPLETED
Weathering the Storm: Lung, Heart, and Brain Vascular Rehabilitation for COVID-19	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a PLA2G6 binder may also engage these)

Protein	Name	Similarity
P97570	—	0.999	P97570 →
A0A3L7I2I8	—	0.999	A0A3L7I2I8 →
P97819	—	0.998	P97819 →
A7MB89	—	0.972	A7MB89 →
Q8CEF1	—	0.972	Q8CEF1 →
Q2T9K6	—	0.971	Q2T9K6 →
Q5RF15	—	0.971	Q5RF15 →
Q6NYU2	—	0.968	Q6NYU2 →
Q29RM5	—	0.968	Q29RM5 →
Q5GIG6	—	0.968	Q5GIG6 →
Q9Z2G1	—	0.968	Q9Z2G1 →
Q7T3P8	—	0.968	Q7T3P8 →
Q9BSK4	—	0.966	Q9BSK4 →
Q9NXN4	—	0.966	Q9NXN4 →
Q96Q27	—	0.966	Q96Q27 →
Q91W86	—	0.965	Q91W86 →
Q5ZJV4	—	0.964	Q5ZJV4 →
Q6B858	—	0.964	Q6B858 →
Q28C34	—	0.964	Q28C34 →
Q4V890	—	0.964	Q4V890 →
Q5U2S6	—	0.964	Q5U2S6 →
Q96JP0	—	0.964	Q96JP0 →
Q2KIX2	—	0.963	Q2KIX2 →
HELZ	Probable helicase with zinc finger domain	0.963	landscape →
Q8K0L0	—	0.963	Q8K0L0 →
A0FKG7	—	0.963	A0FKG7 →
Q7TQP6	—	0.963	Q7TQP6 →
Q9TS33	—	0.963	Q9TS33 →
Q8BPM2	—	0.962	Q8BPM2 →
Q32PW3	—	0.962	Q32PW3 →