Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14034284 | 0.81 | GDA (0.41) | GDAPARP1HSD17B10CYP2C19GAA | |
| SCHEMBL28543470 | 0.79 | GDA (0.40) | GDAPARP1HSD17B10CYP2C19GAA | |
| SCHEMBL1059195 | 0.78 | GDA (0.39) | GDAPARP1HSD17B10CYP2C19GAA | |
| SCHEMBL15131350 | 0.78 | GDA (0.39) | GDAPARP1HSD17B10CYP2C19GAA | |
| SCHEMBL4210787 | 0.78 | GDA (0.39) | GDAPARP1HSD17B10CYP2C19GAA | |
| SCHEMBL12259351 | 0.77 | MAPK1 (0.40) | GDAPAX8SMN1; SMN2 | |
| SCHEMBL8024 | 0.75 | — | — | |
| SCHEMBL28386283 | 0.75 | GDA (0.37) | GDAPARP1HSD17B10CYP2C19GAA | |
| SCHEMBL24600749 | 0.74 | XDH (0.46) | GDAGAAALDH1A1LMNAL3MBTL1 | |
| Mtic SCHEMBL826375 | 0.74 | GDA (0.36) | GDAPARP1HSD17B10CYP2C19GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737284-B2 | Synthesis of temozolomide and analogs | SCHERING PLOUGH CORP. (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090023919-A1 | SYNTHESIS OF TEMOZOLOMIDE AND ANALOGS | SCHERING CORPORATION | 2009-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023919-A1 | SYNTHESIS OF TEMOZOLOMIDE AND ANALOGS | MGMT, TYMS, MCL1 | GDA 122/4885PARP1 45/4885HSD17B10 3171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.