Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13313483 | 0.80 | PARP1 (0.50) | PARP1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13313484 | 0.78 | PARP1 (0.51) | PARP1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13313481 | 0.76 | PARP1 (0.50) | PARP1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13313480 | 0.76 | PARP1 (0.47) | PARP1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL4060250 | 0.76 | KDM4E (0.65) | PARP1KDM4EHTTAURKAALDH1A1 | |
| SCHEMBL917825 | 0.74 | SERPINE1 (0.58) | PARP1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL13439341 | 0.74 | PARP1 (0.44) | PARP1KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14933613 | 0.72 | PARP1 (0.77) | PARP1KDM4ECYP1A2AURKAHSP90AA1 | |
| SCHEMBL3241364 | 0.71 | KDM4E (0.61) | KDM4ECYP1A2HTTSLC6A2HSP90AA1 | |
| SCHEMBL2442863 | 0.71 | PARP1 (0.69) | PARP1KDM4EAURKAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | ACHE, PSEN1, PSEN2 | PARP1 3308/4885KDM4E 3329/4885CYP1A2 1906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.