Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 5/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.30 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12344413 | 0.87 | NPC1 (0.36) | EGLN2NPC1MAPTRAB9AKMT2A | |
| SCHEMBL2768010 | 0.86 | AR (0.31) | AR | |
| SCHEMBL13348785 | 0.86 | GPR119 (0.33) | EGLN2IKBKBCHUKAAK1GPR119 | |
| SCHEMBL12344628 | 0.85 | JAK2 (0.33) | IKBKBCHUK | |
| SCHEMBL2767744 | 0.82 | IKBKB (0.44) | IKBKBCHUK | |
| SCHEMBL12344354 | 0.81 | TGFBR1 (0.35) | IKBKBCHUK | |
| SCHEMBL12344316 | 0.80 | CHUK (0.37) | IKBKBCHUK | |
| SCHEMBL2768634 | 0.78 | MAPT (0.31) | NPC1MAPTRAB9AKMT2AIKBKB | |
| SCHEMBL2766844 | 0.77 | JAK2 (0.33) | — | |
| SCHEMBL12341949 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737279-B2 | 1,6-dihydro-1,3,5,6-tetraaza-as-indacene based tricyclic compounds and pharmaceutical compositions comprising same | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-06-15 | — | — | US | disclosed |