Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 10/20 | 0.53 |
| ▸ | ICOS | Q9Y6W8 | 10/20 | 0.53 |
| ▸ | CHUK | O15111 | 13/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.39 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315655 | 0.91 | ICOSLG (0.65) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653318 | 0.89 | ICOSLG (0.56) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13847526 | 0.89 | ICOSLG (0.48) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653329 | 0.86 | ICOSLG (0.48) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13349346 | 0.85 | ICOSLG (0.48) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13442369 | 0.85 | ICOSLG (0.48) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653424 | 0.85 | ICOSLG (0.49) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653023 | 0.85 | ICOSLG (0.49) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653368 | 0.84 | ICOSLG (0.45) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653020 | 0.83 | ICOSLG (0.46) | ICOSLGICOSCHUKMEN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |