Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICOSLG | O75144 | 8/20 | 0.48 |
| ▸ | ICOS | Q9Y6W8 | 8/20 | 0.48 |
| ▸ | CHUK | O15111 | 11/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12653122 | 0.92 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13408021 | 0.92 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13349346 | 0.92 | ICOSLG (0.48) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653362 | 0.91 | ICOSLG (0.45) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL12653013 | 0.89 | ICOSLG (0.46) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13349345 | 0.89 | ICOSLG (0.46) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13442558 | 0.89 | ICOSLG (0.46) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13349410 | 0.89 | ICOSLG (0.45) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13315669 | 0.86 | ICOSLG (0.59) | ICOSLGICOSCHUKMEN1IKBKB | |
| SCHEMBL13349318 | 0.85 | ICOSLG (0.53) | ICOSLGICOSCHUKMEN1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100093713-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093713-A1 | BETA-CARBOLINES USEFUL FOR TREATING INFLAMMATORY DISEASE | NFKBIA, NFKB2, IKBKG | ICOSLG 2200/4885ICOS 589/4885CHUK 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.