Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Galactose SCHEMBL423422 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL29844979 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Galactose SCHEMBL31555927 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL3630269 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL21456966 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Galactose SCHEMBL30458008 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL29395609 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL13277644 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL8560244 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL177710 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106386034-B | Soil erosion treatment method | 佳木斯大学 | 2019-12-31 | — | — | CN | claimed |
| CN-110423708-A | A kind of wood glucose acetobacter and its application | GAO XIANFENG | 2019-11-08 | — | — | CN | claimed |
| CN-105754894-B | One plant of coconut fermentation strain and the method for producing coconut with the strain fermentation | 无锡市善源生物科技有限公司 | 2019-05-24 | — | — | CN | claimed |
| CN-109700008-A | Chinese medicine tradition five-color health preserving fermented food and preparation method thereof | 中国科学院天津工业生物技术研究所 | 2019-05-03 | — | — | CN | claimed |
| CN-109554430-A | Fully fermented bacterial cellulose membrane and production method and application thereof | 华南协同创新研究院 | 2019-04-02 | — | — | CN | claimed |
| CN-109258335-A | A kind of Gnotobiotic vegetable planting method | 遵义醉美泸江生态农业发展有限公司 | 2019-01-25 | — | — | CN | claimed |
| CN-109007148-A | A kind of fermented tea fermented tea beverage and preparation method thereof | 新希望乳业股份有限公司 | 2018-12-18 | — | — | CN | claimed |
| CN-108902931-A | A kind of composite enzyme of relieving mental strain and helping sleep and preparation method thereof | 惠州嘉联生物科技开发有限公司 | 2018-11-30 | — | — | CN | claimed |
| CN-108902930-A | A kind of composite enzyme and preparation method thereof for helping to improve subhealth symptom | 惠州嘉联生物科技开发有限公司 | 2018-11-30 | — | — | CN | claimed |
| CN-108783426-A | A kind of composite enzyme and preparation method thereof adjusting blood glucose balance | 惠州嘉联生物科技开发有限公司 | 2018-11-13 | — | — | CN | claimed |
| CN-106386034-A | Treatment method for soil and water loss | 佳木斯大学 | 2017-02-15 | — | — | CN | claimed |
| CN-106070778-A | Functional fermented tea beverage and preparation method thereof | 上海融扬生物技术有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-105754894-A | Nata de coco fermentation strain and method for producing nata de coco by same | 无锡市善源生物科技有限公司 | 2016-07-13 | — | — | CN | claimed |
| CN-104945117-A | Soil activator | ZHANGJIAGANG SHANMU NEW MATERIAL TECHNOLOGY DEV CO | 2015-09-30 | — | — | CN | claimed |
| CN-103069978-B | Gnotobiotic vegetable planting method | GE CAIBAO | 2015-03-18 | — | — | CN | claimed |
| CN-104411360-A | Medical microelectrode, method for its manufacture, and use thereof | NEURONANO AB | 2015-03-11 | — | — | CN | claimed |
| US-20110275118-A1 | METHOD OF PRODUCING FATTY ACIDS FOR BIOFUEL, BIODIESEL, AND OTHER VALUABLE CHEMICALS | DE CRECY EUDES | 2011-11-10 | — | — | US | claimed |
| WO-2010042842-A2 | A METHOD OF PRODUCING FATTY ACIDS FOR BIOFUEL, BIODIESEL, AND OTHER VALUABLE CHEMICALS | DE CRECY EUDES (US) | 2010-04-15 | — | — | WO | claimed |
| CN-1160357-A | Gas filled microspheres as computed tomography contrast agents | IMARX PHARMACEUTICAL CORP (US) | 1997-09-24 | — | — | CN | claimed |
| EP-0074169-A1 | Micro-biological production of muconic acid | CELANESE CORPORATION (US) | 1983-03-16 | — | — | EP | claimed |