Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Galactose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Demannose SCHEMBL1334995 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL29844979 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Galactose SCHEMBL31555927 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL3630269 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL21456966 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Galactose SCHEMBL30458008 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL29395609 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL13277644 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL8560244 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 | |
| Demannose SCHEMBL177710 | 1.00 | PDE4A (0.50) | PDE4ALMNAL3MBTL1USP2SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707483-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2023-07-25 | — | — | US | disclosed |
| US-20200147121-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2020-05-14 | — | — | US | disclosed |
| US-10420790-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2019-09-24 | — | — | US | disclosed |
| US-20170239360-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2017-08-24 | — | — | US | disclosed |
| US-9662403-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2017-05-30 | — | — | US | disclosed |
| US-20160250338-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2016-09-01 | — | — | US | disclosed |
| US-9339558-B2 | Micellic assemblies | UNIVERSITY OF WASHINGTON (US) | 2016-05-17 | — | — | US | disclosed |
| US-9211250-B2 | Heterogeneous polymeric micelles for intracellular delivery | UNIVERSITY OF WASHINGTON (US) | 2015-12-15 | — | — | US | disclosed |
| US-20150238619-A1 | POLYMERIC CARRIER | PHASERX, INC. (US) | 2015-08-27 | — | — | US | disclosed |
| US-9006193-B2 | Polymeric carrier | UNIVERSITY OF WASHINGTON (US) | 2015-04-14 | — | — | US | disclosed |
| EP-2331069-A1 | HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY | University Of Washington (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20110123636-A1 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2011-05-26 | — | — | US | disclosed |
| EP-2296627-A2 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS | The University of Washington (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2296708-A2 | POLYMERIC CARRIER | University of Washington (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2285853-A2 | MICELLIC ASSEMBLIES | University of Washington (US) | 2011-02-23 | — | — | EP | disclosed |
| WO-2010053597-A2 | MICELLES OF HYDROPHILICALLY SHIELDED MEMBRANE-DESTABILIZING COPOLYMERS | UNIVERSITY OF WASHINGTON/////////////////////-+ (US) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010021770-A1 | HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY | UNIVERSITY OF WASHINGTON (US) | 2010-02-25 | — | — | WO | disclosed |
| WO-2009140429-A2 | MICELLIC ASSEMBLIES | UNIVERSITY OF WASHINGTON (US) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140432-A2 | MICELLES FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS | UNIVERSITY OF WASHINGTON (US) | 2009-11-19 | — | — | WO | disclosed |
| WO-2009140421-A2 | POLYMERIC CARRIER | UNIVERSITY OF WASHINGTON (US) | 2009-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11707483-B2 | Micellic assemblies | UACA, CLPTM1L, BPHL | PDE4A 2344/4885LMNA 1358/4885L3MBTL1 943/4885 |
| US-20160250338-A1 | MICELLIC ASSEMBLIES | CLPX, VCL, ANXA5 | PDE4A 3949/4885LMNA 1110/4885L3MBTL1 891/4885 |
| US-10420790-B2 | Micellic assemblies | UACA, CLPTM1L, BPHL | PDE4A 2344/4885LMNA 1358/4885L3MBTL1 943/4885 |
| US-20200147121-A1 | MICELLIC ASSEMBLIES | CLPX, VCL, ANXA5 | PDE4A 3949/4885LMNA 1110/4885L3MBTL1 891/4885 |
| US-20170239360-A1 | MICELLIC ASSEMBLIES | UACA, CLPTM1L, BPHL | PDE4A 2344/4885LMNA 1358/4885L3MBTL1 943/4885 |
| US-20110123636-A1 | MICELLIC ASSEMBLIES | CLPX, VCL, ANXA5 | PDE4A 3949/4885LMNA 1110/4885L3MBTL1 891/4885 |
| US-20150238619-A1 | POLYMERIC CARRIER | POLI, DCLRE1B, POLRMT | PDE4A 3199/4885LMNA 1178/4885L3MBTL1 356/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.