SCHEMBL133543

SCHEMBL133543

COC(=O)CCC(NC(=O)c1ccc(NCC2CNc3nc(N)[nH]c(=O)c3N2)cc1)C(=O)O

nearest known ligand 0.85

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SOST Q9BQB4 1/20 0.85
FPGS Q05932 2/20 0.84
GART P22102 5/20 0.64
DHFR P00374 1/20 0.58
ATIC P31939 4/20 0.56
MTHFD1 P11586 2/20 0.56
LMNA P02545 1/20 0.49
MTHFD2 P13995 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20509041 1.00 SOST (0.85) SOSTFPGSGARTDHFRATIC
SCHEMBL27903149 1.00 SOST (0.85) SOSTFPGSGARTDHFRATIC
SCHEMBL7077904 1.00 SOST (0.85) SOSTFPGSGARTDHFRATIC
SCHEMBL7076983 1.00 SOST (0.85) SOSTFPGSGARTDHFRATIC
SCHEMBL28206347 0.99 SOST (0.84) SOSTFPGSGARTDHFRATIC
SCHEMBL27284124 0.99 SOST (0.84) SOSTFPGSGARTDHFRATIC
Phosphoric Acid SCHEMBL28313723 0.98 SOST (0.82) SOSTFPGSGARTDHFRATIC
Tetrahydrofolate SCHEMBL27798266 0.98 SOST (0.90) SOSTFPGSGARTDHFRATIC
Glycine SCHEMBL27746532 0.97 SOST (0.83) SOSTFPGSGARTDHFRATIC
Butyric Acid SCHEMBL28187742 0.94 SOST (0.76) SOSTFPGSGARTDHFRATIC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 495 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4687872-A1 ORAL ACTIVE INGREDIENT COMBINATION CONTAINING L-ARGININE, L-CITRULLINE, SELENITE AND WATER-SOLUBLE BORON RFB HealthCare GmbH (DE) 2026-02-11 EP claimed
WO-2024208506-A1 ORAL ACTIVE INGREDIENT COMBINATION CONTAINING L-ARGININE, L-CITRULLINE, SELENITE AND WATER-SOLUBLE BORON RFB HEALTHCARE GMBH (DE) 2024-10-10 WO claimed
US-20230165895-A1 COMPOSITIONS AND METHODS FOR EYE HEAL TH COMPRISING AREDS AND VITAMIN B COMPLEX BAUSCH + LOMB IRELAND LIMITED (IE) 2023-06-01 US claimed
US-20230117576-A1 COMPOSITIONS AND METHODS FOR AGE RELATED EYE DISEASES COMPRISING HIGH CONCENTRATIONS OF VITAMINS BAUSCH + LOMB IRELAND LIMITED (IE) 2023-04-20 US claimed
EP-4117650-A1 COMPOSITIONS AND METHODS FOR EYE HEALTH COMPRISING AREDS AND VITAMIN B COMPLEX Bausch + Lomb Ireland Limited (IE) 2023-01-18 EP claimed
EP-4117649-A1 COMPOSITIONS AND METHODS FOR AGE RELATED EYE DISEASES COMPRISING HIGH CONCENTRATIONS OF VITAMINS Bausch + Lomb Ireland Limited (IE) 2023-01-18 EP claimed
CN-115461048-A Compositions and methods for ocular health comprising AREDS and vitamin B complexes 博士伦爱尔兰有限公司 2022-12-09 CN claimed
CN-114159585-A Special diabetes detection reagent for pregnant women 新昌县越安君生物技术有限公司 2022-03-11 CN claimed
US-11261450-B2 Recombinant cell, method for producing recombinant cell, and method for producing isoprene or terpene SEKISUI CHEMICAL CO., LTD. (JP) 2022-03-01 US claimed
WO-2021181310-A1 COMPOSITIONS AND METHODS FOR EYE HEALTH COMPRISING AREDS AND VITAMIN B COMPLEX BAUSCH HEALTH IRELAND LIMITED (IE) 2021-09-16 WO claimed
US-7955828-B2 identification of novel fungicidal compounds; diseases due to pathogenic plant fungi belonging to the ascomycete, basidiomycete and oomycete families BAYER CROPSCIENCE AG (DE) 2011-06-07 US claimed
CN-101978042-A Methods and organisms for utilizing syngas or other gaseous carbon sources and methanol GENOMATICA INC 2011-02-16 CN claimed
CN-101897709-A Drug composition containing small dosage of folic acid and aspirin and application thereof BEIJING AOSA PHARMED RES CT CO LTD 2010-12-01 CN claimed
US-20100009416-A1 Process for the Preparation of L-Methionine EVONIK DEGUSSA GMBH (DE) 2010-01-14 US claimed
CN-101454460-A Process for the preparation of L-methionine EVONIK DEGUSSA GMBH (DE) 2009-06-10 CN claimed
EP-2019868-A2 PROCESS FOR THE PREPARATION OF L-METHIONINE Evonik Degussa GmbH (DE) 2009-02-04 EP claimed
EP-1831391-B1 USE OF METHIONINE SYNTHASE INHIBITORS FOR THE TREATMENT OF FUNGAL DISEASES OF CROPS BAYER CROPSCIENCE SA (FR) 2008-12-31 EP claimed
CN-101273024-A Novel benzo[D][1,3]-dioxol derivatives CONCERT PHARMACEUTICALS INC (US) 2008-09-24 CN claimed
US-20080132586-A1 Use of Methionine Synthase Inhibitors for the Treatment of Fungal Diseases of Crops BAYER CROPSCIENCE AG (DE) 2008-06-05 US claimed
WO-2007135188-A2 PROCESS FOR THE PREPARATION OF L-METHIONINE EVONIK DEGUSSA GMBH (DE) 2007-11-29 WO claimed