Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 11/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 11/20 | 0.51 |
| ▸ | AURKA | O14965 | 7/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
| ▸ | DCK | P27707 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318488 | 0.89 | PDPK1 (0.48) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122773 | 0.88 | PDPK1 (0.50) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122793 | 0.85 | PDPK1 (0.53) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354853 | 0.84 | PDPK1 (0.72) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1317857 | 0.83 | PDPK1 (0.74) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122694 | 0.83 | PDPK1 (0.58) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354798 | 0.82 | PDPK1 (0.53) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354766 | 0.81 | PDPK1 (0.62) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122780 | 0.81 | PDPK1 (0.71) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354725 | 0.80 | PDPK1 (0.70) | PDPK1AURKBAURKAROCK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |