Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 12/20 | 0.72 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.72 |
| ▸ | AURKA | O14965 | 10/20 | 0.72 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119114 | 0.90 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119499 | 0.90 | PDPK1 (0.67) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122694 | 0.87 | PDPK1 (0.58) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122793 | 0.85 | PDPK1 (0.53) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354719 | 0.84 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119122 | 0.84 | PDPK1 (1.00) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119515 | 0.84 | PDPK1 (1.00) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12122773 | 0.82 | PDPK1 (0.50) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL13354870 | 0.81 | PDPK1 (0.86) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119179 | 0.81 | AURKA (0.63) | PDPK1AURKBAURKAPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |