Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 10/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 10/20 | 0.67 |
| ▸ | AURKA | O14965 | 8/20 | 0.67 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12119499 | 1.00 | PDPK1 (0.67) | PDPK1AURKBAURKAKDM4DROCK1 | |
| SCHEMBL12119531 | 0.91 | PDPK1 (0.55) | PDPK1AURKBAURKAKDM4DROCK1 | |
| SCHEMBL13354853 | 0.90 | PDPK1 (0.72) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL3126962 | 0.89 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL16966440 | 0.89 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL1318419 | 0.89 | PDPK1 (0.51) | PDPK1AURKBAURKAROCK1TGFBR1 | |
| SCHEMBL12119301 | 0.88 | PDPK1 (0.54) | PDPK1AURKBAURKAROCK1EGLN2 | |
| SCHEMBL12119789 | 0.86 | PDPK1 (0.67) | PDPK1AURKBAURKAKDM4DSUV39H2 | |
| SCHEMBL16977385 | 0.86 | PDPK1 (0.67) | PDPK1AURKBAURKAKDM4DSUV39H2 | |
| SCHEMBL12119175 | 0.86 | PDPK1 (0.50) | PDPK1AURKBAURKAROCK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-08-05 | — | — | EP | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
| US-20110275611-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275611-A1 | CHEMICAL COMPOUNDS | PDK1, PDK2, PDK3 | PDPK1 12/4885AURKB 262/4885AURKA 298/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.