Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | SMO | Q99835 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162185 | 0.78 | CA12 (0.45) | PLA2G1BATG4BACHEKMT2AALDH1A1 | |
| SCHEMBL12169333 | 0.72 | NOTUM (0.49) | — | |
| SCHEMBL13385734 | 0.72 | RECQL (0.50) | KMT2AKDM4EALDH1A1HPGDNAMPT | |
| SCHEMBL13355240 | 0.71 | KDM4E (0.48) | KMT2AKDM4EALDH1A1HPGDNAMPT | |
| SCHEMBL9928309 | 0.71 | HPGD (0.61) | ACHECCR5ALDH1A1HPGD | |
| SCHEMBL13354704 | 0.70 | PGR (0.42) | KMT2AKDM4EMAOAPGRALDH1A1 | |
| SCHEMBL13079622 | 0.70 | GAA (0.47) | KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL12115285 | 0.70 | KMT2A (0.44) | KMT2AKDM4EALDH1A1HTT | |
| SCHEMBL4818101 | 0.70 | CRBN (0.56) | ACHECCR5ALDH1A1HPGD | |
| SCHEMBL4818087 | 0.70 | CRBN (0.56) | ACHECCR5ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1787982-B1 | 11Beta-Hydroxysteroid dehydrogenase type 1 active compounds | HIGH POINT PHARMACEUTICALS LLC (US) | 2010-05-12 | — | — | EP | disclosed |
| US-7700583-B2 | Such as [4-(1,3,3-Trimethyl-6-aza-bicyclo[3.2.1]octane-6-carbonyl)-phenyl]carbamic acid tert-butyl ester; for treatment of metabolic syndrome | HIGH POINT PHARMACEUTICALS, LLC (US) | 2010-04-20 | — | — | US | disclosed |