Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
| ▸ | HTR3B | O95264 | 1/20 | 0.44 |
| ▸ | HTR3A | P46098 | 1/20 | 0.44 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.44 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16443508 | 0.78 | GRIN2B (0.67) | LMNAMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL27942162 | 0.78 | NPC1 (0.83) | LMNANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL25375732 | 0.78 | NPC1 (0.66) | LMNANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL28992287 | 0.71 | ERCC1 (0.68) | LMNANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL25376216 | 0.71 | ALDH1A1 (0.66) | LMNASMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL16584664 | 0.71 | ALDH1A1 (0.56) | LMNANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL5269588 | 0.71 | GRIN2D (0.53) | L3MBTL1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL973274 | 0.70 | NPC1 (0.54) | LMNANPC1RAB9AL3MBTL1SMN1; SMN2 | |
| SCHEMBL11583324 | 0.70 | CYP1A2 (0.64) | LMNAMEN1KMT2APOLBGRIN1 | |
| SCHEMBL11583321 | 0.70 | CYP1A2 (0.64) | LMNAMEN1KMT2APOLBGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |