Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | GABRP | O00591 | 1/20 | 0.55 |
| ▸ | GABRD | O14764 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.55 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27942162 | 0.90 | NPC1 (0.83) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL3056874 | 0.83 | KMT2A (0.71) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL28992287 | 0.83 | ERCC1 (0.68) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL3561653 | 0.82 | NPC1 (0.75) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL30858769 | 0.80 | NPC1 (1.00) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL15678783 | 0.79 | ALDH1A1 (0.68) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL11124878 | 0.78 | NPC1 (0.64) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL28193159 | 0.78 | GABRP (0.56) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL13357558 | 0.78 | LMNA (0.50) | NPC1RAB9AL3MBTL1MEN1KMT2A | |
| SCHEMBL2912570 | 0.77 | SMN1; SMN2 (0.82) | NPC1RAB9AL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |