Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 13/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 13/20 | 0.70 |
| ▸ | ABL1 | P00519 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13357581 | 0.86 | ROCK1 (0.60) | ROCK2ROCK1ABL1MEN1KMT2A | |
| SCHEMBL13357606 | 0.86 | ROCK1 (0.70) | ROCK2ROCK1MAPTSMN1; SMN2 | |
| SCHEMBL14740347 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1MEN1MAPTKMT2A | |
| SCHEMBL14738942 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1MEN1MAPTKMT2A | |
| SCHEMBL2561224 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1MEN1MAPTKMT2A | |
| SCHEMBL13357574 | 0.80 | ROCK1 (0.66) | ROCK2ROCK1MEN1MAPTKMT2A | |
| SCHEMBL13357663 | 0.80 | ROCK1 (0.59) | ROCK2ROCK1BLM | |
| SCHEMBL13357633 | 0.79 | ROCK1 (0.65) | ROCK2ROCK1MEN1MAPTKMT2A | |
| SCHEMBL13357658 | 0.75 | ROCK1 (0.68) | ROCK2ROCK1MAPTSMN1; SMN2 | |
| SCHEMBL3257615 | 0.75 | ROCK1 (0.68) | ROCK2ROCK1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558607-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |