Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 14/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.55 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13357606 | 0.83 | ROCK1 (0.70) | ROCK1ROCK2PARP1PRKACAMAPT | |
| SCHEMBL13357581 | 0.81 | ROCK1 (0.60) | ROCK1ROCK2PARP1BLMMEN1 | |
| SCHEMBL2557346 | 0.80 | ROCK1 (1.00) | ROCK1ROCK2CLK1PARP1BLM | |
| SCHEMBL13357607 | 0.80 | ROCK2 (0.70) | ROCK1ROCK2BLMMAPTMEN1 | |
| SCHEMBL13357693 | 0.77 | ROCK1 (0.53) | ROCK1ROCK2CLK1PARP1MAPT | |
| SCHEMBL13357633 | 0.76 | ROCK1 (0.65) | ROCK1ROCK2CLK1PRKACAMAPT | |
| SCHEMBL2557871 | 0.76 | ROCK1 (1.00) | ROCK1ROCK2 | |
| SCHEMBL13357576 | 0.75 | ROCK1 (0.67) | ROCK1ROCK2CLK1PARP1PRKACA | |
| SCHEMBL13357658 | 0.75 | ROCK1 (0.68) | ROCK1ROCK2PARP1PRKACAMAPT | |
| SCHEMBL3257615 | 0.75 | ROCK1 (0.68) | ROCK1ROCK2PARP1PRKACAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1558607-B1 | COMPOSITIONS USEFUL AS INHIBITORS OF ROCK AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2010-05-05 | — | — | EP | disclosed |