SCHEMBL13357948

SCHEMBL13357948

Cc1cc(N2C[C@H](CN)OC2=O)cc(F)c1N1CCNN(Cc2ccccn2)CC1

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CALML3 P27482 3/20 0.36
MAOA P21397 6/20 0.35
F10 P00742 1/20 0.35
GRM2 Q14416 2/20 0.35
CYP3A4 P08684 1/20 0.34
CHRM4 P08173 1/20 0.34
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
GFER P55789 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10152108 0.88 MAOA (0.48) CALML3MAOAF10CHRM4LMNA
SCHEMBL10152013 0.86 MAOA (0.40) CALML3MAOAF10CHRM4LMNA
SCHEMBL13367808 0.85 CYP3A4 (0.40) CALML3MAOAF10GRM2CYP3A4
SCHEMBL13358180 0.79 MAOA (0.43) CALML3MAOAF10GRM2CHRM4
SCHEMBL13358120 0.79 MAOA (0.42) CALML3MAOAF10GRM2
SCHEMBL10151841 0.76 MAOB (0.62) CALML3MAOAF10LMNA
SCHEMBL13367993 0.76 MAOA (0.41) CALML3MAOAF10CYP3A4LMNA
SCHEMBL13358118 0.75 MAOA (0.43) CALML3MAOAF10LMNA
SCHEMBL11983842 0.74 MAOA (0.50) CALML3MAOAF10LMNA
SCHEMBL10151843 0.74 F10 (0.50) CALML3MAOAF10LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2181994-A1 Antimicrobial compounds Research Foundation Itsuu Laboratory (JP) 2010-05-05 EP disclosed