Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | HRH1 | P35367 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
| ▸ | HTR2C | P28335 | 2/20 | 0.52 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | RAD52 | P43351 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359373 | 0.87 | SLC6A3 (0.47) | SLC6A3DRD2HRH1DRD4HTR2C | |
| SCHEMBL13359372 | 0.84 | SLC6A3 (0.45) | SLC6A3DRD2HRH1DRD4HTR2C | |
| SCHEMBL14393844 | 0.83 | SLC6A3 (0.45) | SLC6A3DRD2HRH1DRD4HTR2C | |
| SCHEMBL13359371 | 0.82 | SLC6A3 (0.43) | SLC6A3CYP1A2TSHRCYP2C19MEN1 | |
| SCHEMBL3285765 | 0.77 | SLC6A3 (1.00) | SLC6A3DRD2HRH1DRD4HTR2C | |
| SCHEMBL30978858 | 0.77 | SLC6A3 (1.00) | SLC6A3DRD2HRH1DRD4HTR2C | |
| SCHEMBL13359375 | 0.71 | MAPT (0.36) | SLC6A3DRD2HTR2CTP53RAD52 | |
| SCHEMBL18310354 | 0.70 | DRD2 (0.81) | SLC6A3DRD2HRH1DRD4HTR2C | |
| Clorotepine SCHEMBL678917 | 0.68 | DRD2 (1.00) | DRD2HRH1DRD4HTR2CKCNK9 | |
| Clorotepine SCHEMBL29822559 | 0.68 | DRD2 (1.00) | DRD2HRH1DRD4HTR2CKCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713956-B2 | Dealkylated derivatives of pyrrolo[2,1-b]benzothiazepines with atypical antipsychotic activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-05-11 | — | — | US | disclosed |
| US-20070270402-A1 | Dealkylated Derivatives of Pyrrolo[2,1-B]Benzothiazepines with Atypical Antipsy-Chotic Activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270402-A1 | Dealkylated Derivatives of Pyrrolo[2,1-B]Benzothiazepines with Atypical Antipsy-Chotic Activity | CNR1, HRH4, CNR2 | SLC6A3 405/4885DRD2 16/4885HRH1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.