Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 4/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.56 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1336412 | 0.95 | POLB (0.70) | SMOPOLBALDH1A1PKMMEN1 | |
| SCHEMBL1336746 | 0.87 | TRPV1 (0.76) | SMOPOLBALDH1A1PKMTRPV1 | |
| SCHEMBL1336765 | 0.85 | ALDH1A1 (0.74) | SMOPOLBALDH1A1PKMMEN1 | |
| SCHEMBL12129968 | 0.84 | SMO (1.00) | SMOCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL10238305 | 0.81 | KCNK9 (0.69) | SMOPOLBALDH1A1PKMMEN1 | |
| SCHEMBL1335450 | 0.81 | KCNK9 (0.85) | SMOPOLBALDH1A1TRPV1MEN1 | |
| SCHEMBL10238385 | 0.80 | MEN1 (0.70) | SMOPOLBALDH1A1PKMMEN1 | |
| SCHEMBL12129951 | 0.80 | SMO (0.89) | SMOMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL1336818 | 0.79 | KCNK3 (0.69) | SMOALDH1A1PKMMEN1KMT2A | |
| SCHEMBL1337377 | 0.78 | KCNK9 (0.74) | SMOPOLBALDH1A1PKMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291352-B1 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NAT RECH SCIENT (FR) | 2017-09-13 | — | — | EP | claimed |
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | claimed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | claimed |
| EP-2291352-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | Centre National de la Recherche Scientifique (FR) | 2011-03-09 | — | — | EP | claimed |
| WO-2009130422-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-29 | — | — | WO | claimed |
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | disclosed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | disclosed |
| EP-2291352-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | Centre National de la Recherche Scientifique (FR) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009130422-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | SHH, GLI1, SMO | SMO 3/4885POLB 4665/4885ALDH1A1 2206/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.