Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.76 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.75 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 5/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | SMO | Q99835 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1335450 | 0.94 | KCNK9 (0.85) | TRPV1KCNK9KCNK3KMT2AMEN1 | |
| SCHEMBL1337377 | 0.91 | KCNK9 (0.74) | KCNK9KCNK3KMT2AMEN1POLB | |
| SCHEMBL1337469 | 0.89 | TRPV1 (0.72) | TRPV1KCNK9KCNK3KMT2AMEN1 | |
| SCHEMBL1337518 | 0.88 | KCNK9 (0.84) | TRPV1KCNK9KCNK3KMT2AMEN1 | |
| SCHEMBL12259160 | 0.88 | SIRT1 (0.69) | TRPV1KCNK9KCNK3KMT2AMEN1 | |
| SCHEMBL1336818 | 0.87 | KCNK3 (0.69) | KCNK9KCNK3KMT2AMEN1NPC1 | |
| SCHEMBL1337555 | 0.87 | NPC1 (0.73) | KCNK9KCNK3KMT2AMEN1POLB | |
| SCHEMBL4253111 | 0.87 | TRPV1 (1.00) | TRPV1KCNK9KCNK3KMT2AMEN1 | |
| SCHEMBL1336216 | 0.87 | SMO (0.73) | TRPV1KCNK9KCNK3KMT2AMEN1 | |
| SCHEMBL12129846 | 0.83 | SMO (0.87) | TRPV1KMT2AMEN1POLBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | claimed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | claimed |
| EP-2291352-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | Centre National de la Recherche Scientifique (FR) | 2011-03-09 | — | — | EP | claimed |
| WO-2009130422-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-29 | — | — | WO | claimed |
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | disclosed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | disclosed |
| EP-2291352-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | Centre National de la Recherche Scientifique (FR) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009130422-A2 | N-ACYLTHIOUREA AND N-ACYLUREA INHIBITORS OF THE HEDGEHOG PROTEIN SIGNALLING PATHWAY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | SHH, GLI1, SMO | TRPV1 3310/4885KCNK9 4296/4885KCNK3 4400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.