Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.46 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | JUN | P05412 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 6/20 | 0.38 |
| ▸ | TTK | P33981 | 3/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 5/20 | 0.37 |
| ▸ | CDK1 | P06493 | 5/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12671430 | 0.88 | MAP4K1 (0.46) | MAP4K1MAP4K3JAK1TYK2JAK3 | |
| SCHEMBL13251910 | 0.83 | MAP4K1 (0.43) | MAP4K1MAP4K3JUNMAPK8MAPK10 | |
| SCHEMBL1571409 | 0.82 | MAP4K1 (0.42) | MAP4K1MAP4K3JAK1TYK2JAK3 | |
| SCHEMBL14146275 | 0.81 | MAP4K1 (0.40) | MAP4K1MAP4K3JAK1TYK2JAK3 | |
| SCHEMBL13362640 | 0.81 | DYRK1A (0.48) | MAP4K1MAP4K3CLK2CLK3DYRK1A | |
| SCHEMBL13362896 | 0.81 | MAP4K1 (0.43) | MAP4K1MAP4K3JUNMAPK8MAPK10 | |
| SCHEMBL13362643 | 0.78 | CHEK1 (0.48) | MAP4K1MAP4K3JAK1TYK2JAK3 | |
| SCHEMBL13362817 | 0.78 | MAP4K1 (0.44) | MAP4K1MAP4K3JUNMAPK8MAPK10 | |
| SCHEMBL13362797 | 0.76 | TTK (0.44) | MAP4K1MAP4K3JUNMAPK8MAPK10 | |
| SCHEMBL13362641 | 0.76 | GRM2 (0.44) | MAP4K1MAP4K3DYRK1ADDR2TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | JAIN RAMA | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100121052-A1 | Novel compounds for treating proliferative diseases | PDK1, PDK2, PDK3 | MAP4K1 112/4885MAP4K3 103/4885JAK1 1597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.