Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13947533 | 0.90 | HTR6 (0.48) | MAPTKMT2AMEN1RAPGEF4POLB | |
| SCHEMBL3036911 | 0.83 | PPARG (0.56) | MAPTKMT2AMEN1POLBALDH1A1 | |
| SCHEMBL10271492 | 0.75 | HASPIN (0.46) | MAPTALDH1A1 | |
| SCHEMBL3030572 | 0.74 | PPARG (0.62) | MAPTKMT2APOLBHTR6ALDH1A1 | |
| SCHEMBL9948843 | 0.73 | HTR6 (0.48) | MAPTKMT2AMEN1HTR6ALDH1A1 | |
| SCHEMBL6970702 | 0.68 | HTR6 (0.47) | MAPTKMT2AMEN1POLBPKM | |
| SCHEMBL30302199 | 0.67 | ALDH1A1 (0.49) | MAPTKMT2ARAB9AHTR6ALDH1A1 | |
| SCHEMBL10271494 | 0.66 | HSD17B10 (0.45) | MAPTKMT2AMEN1POLBHTR6 | |
| SCHEMBL6968667 | 0.66 | HTR6 (0.48) | MAPTKMT2AMEN1POLBPKM | |
| SCHEMBL11130954 | 0.65 | MAPT (0.53) | MAPTKMT2AMEN1POLBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723374-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2010-05-25 | — | — | US | disclosed |
| US-7491831-B2 | PPAR active compounds | PLEXXIKON, INC. (US) | 2009-02-17 | — | — | US | disclosed |