SCHEMBL13369692

SCHEMBL13369692

CC1CN(c2ccc(C(F)(F)F)cn2)CC(C)N1CC(=O)N1CCc2nn(CC(F)(F)F)cc2C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.41
SMN1; SMN2 Q16637 5/20 0.40
HPGD P15428 1/20 0.40
HRH3 Q9Y5N1 2/20 0.39
CXCR3 P49682 1/20 0.39
KDM4E B2RXH2 5/20 0.38
HCRTR1 O43613 3/20 0.38
HCRTR2 O43614 3/20 0.38
LMNA P02545 3/20 0.38
ABL1 P00519 1/20 0.38
MEN1 O00255 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
KMT2A Q03164 1/20 0.37
MAPT P10636 3/20 0.37
ALDH1A1 P00352 2/20 0.37
POLB P06746 2/20 0.37
THRB P10828 1/20 0.37
EIF2AK4 Q9P2K8 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2177506 1.00 HSD11B1 (0.41) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
Oxalic Acid SCHEMBL12540524 0.98 HSD11B1 (0.39) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL2181624 0.93 SMN1; SMN2 (0.42) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL13369694 0.93 SMN1; SMN2 (0.42) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL13369693 0.89 HSD11B1 (0.42) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL2177903 0.89 HSD11B1 (0.42) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL2178338 0.89 HSD11B1 (0.42) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL12540494 0.87 HSD11B1 (0.42) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL12541660 0.86 CXCR3 (0.41) HSD11B1SMN1; SMN2HPGDHRH3CXCR3
SCHEMBL12542035 0.84 CXCR3 (0.43) HSD11B1SMN1; SMN2HPGDHRH3CXCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2513108-A1 NOVEL (HETEROCYCLE/CONDENSED PIPERIDINE)-(PIPERAZINYL)-1-ALCANONE OR (HETEROCYCLE/CONDENSED PYRROLIDINE)-(PIPERAZINYL)-1-ALCANONE DERIVATIVES, AND USE THEREOF AS P75 INHIBITORS SANOFI (FR) 2012-10-24 EP claimed
EP-2513108-A1 NOVEL (HETEROCYCLE/CONDENSED PIPERIDINE)-(PIPERAZINYL)-1-ALCANONE OR (HETEROCYCLE/CONDENSED PYRROLIDINE)-(PIPERAZINYL)-1-ALCANONE DERIVATIVES, AND USE THEREOF AS P75 INHIBITORS SANOFI (FR) 2012-10-24 EP disclosed