Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874895 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL4874887 | 0.82 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL4957949 | 0.82 | HPGD (0.52) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL4957945 | 0.82 | HPGD (0.52) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL3694739 | 0.73 | ERN1 (0.41) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL21175834 | 0.73 | HPGD (0.42) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL20096102 | 0.69 | TSHR (0.38) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL12416946 | 0.68 | HPGD (0.62) | ALDH1A1HPGDMAPTGAAMAPK1 | |
| SCHEMBL2893633 | 0.68 | MAOB (0.59) | ALDH1A1MAPTGAAMEN1KMT2A | |
| SCHEMBL2893630 | 0.68 | MAOB (0.59) | ALDH1A1MAPTGAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056788-A1 | ANTI-HYPERCHOLESTEROLEMIC COMPOUNDS | MERCK SHARP & DOHME CORP. (US) | 2010-05-20 | — | — | WO | disclosed |