Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LIG1 | P18858 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4957949 | 1.00 | HPGD (0.52) | HPGDALDH1A1MAPK1TSHRHSD17B10 | |
| SCHEMBL4874895 | 0.87 | ALDH1A1 (0.53) | HPGDALDH1A1MAPK1TSHRHSD17B10 | |
| SCHEMBL4874887 | 0.87 | ALDH1A1 (0.53) | HPGDALDH1A1MAPK1TSHRHSD17B10 | |
| SCHEMBL1878476 | 0.83 | HPGD (0.50) | HPGDALDH1A1MAPK1TSHRMAOB | |
| SCHEMBL4430794 | 0.82 | MAOB (0.60) | MAOBSMN1; SMN2LMNA | |
| SCHEMBL13886069 | 0.82 | MAOB (0.60) | MAOBSMN1; SMN2LMNA | |
| SCHEMBL4430797 | 0.82 | MAOB (0.60) | MAOBSMN1; SMN2LMNA | |
| SCHEMBL13372072 | 0.82 | ALDH1A1 (0.47) | HPGDALDH1A1MAPK1TSHRHSD17B10 | |
| SCHEMBL13786439 | 0.80 | MAOB (0.46) | HPGDALDH1A1MAPK1TSHRMAOB | |
| SCHEMBL14206846 | 0.75 | MAOB (0.65) | ALDH1A1MAOBMAPTGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA, INC. (US) | 2008-07-10 | — | — | US | disclosed |
| US-7320972-B2 | 4-Biarylyl-1-phenylazetidin-2-ones | MICROBIA, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7320972-B2 | 4-Biarylyl-1-phenylazetidin-2-ones | MICROBIA, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7320972-B2 | 4-Biarylyl-1-phenylazetidin-2-ones | MICROBIA, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1832576-A1 | 4-Biarylyl-1-phenolyzetidin-2-ones | Microbia Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1832576-A1 | 4-Biarylyl-1-phenolyzetidin-2-ones | Microbia Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1682499-B1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA INC (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1682499-B1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | MICROBIA INC (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | IRONWOOD PHARMACEUTICALS, INC. | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167255-A1 | 4-BIARYLYL-1-PHENYLAZETIDIN-2-ONES | APOB, CYP46A1, PCSK9 | HPGD 2215/4885ALDH1A1 848/4885MAPK1 2917/4885 |
| US-20050209165-A1 | 4-Biarylyl-1-phenylazetidin-2-ones | APOB, CYP46A1, PCSK9 | HPGD 2215/4885ALDH1A1 848/4885MAPK1 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.