Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13374368 | 0.80 | KDM4E (0.60) | ACHEBACE1BCHEALDH1A1TDP1 | |
| SCHEMBL13375733 | 0.79 | ALDH1A1 (0.39) | CHKAALDH1A1TDP1KDM4ESMN1; SMN2 | |
| SCHEMBL13374337 | 0.75 | BCHE (0.55) | MGAT2ACHEBACE1BCHE | |
| SCHEMBL13374352 | 0.75 | ALDH1A1 (0.59) | MGAT2ACHEALDH1A1KDM4ETRPV6 | |
| SCHEMBL12437243 | 0.74 | ALDH1A1 (0.60) | ACHEALDH1A1SMN1; SMN2SIGMAR1 | |
| SCHEMBL13374344 | 0.73 | ATM (0.58) | ACHEALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL13374359 | 0.73 | PDE2A (0.43) | MGAT2ALDH1A1KDM4EGAATRPV6 | |
| SCHEMBL19075602 | 0.73 | PDE2A (0.43) | MGAT2ALDH1A1TDP1KDM4ESMN1; SMN2 | |
| SCHEMBL19075547 | 0.73 | ACKR3 (0.45) | MGAT2S1PR5ALDH1A1KDM4E | |
| SCHEMBL19075811 | 0.72 | BCHE (0.46) | MGAT2ACHEBACE1BCHEALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288381-B2 | N-9 substituted purine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-10-16 | — | — | US | disclosed |