Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13375252 | 0.91 | AURKA (0.36) | KMT2AHDAC1HDAC2KDM4ERAB9A | |
| SCHEMBL13373942 | 0.86 | KMT2A (0.41) | KMT2ACYP3A4PRSS12HRH4CHEK1 | |
| SCHEMBL13373931 | 0.84 | SYK (0.45) | KMT2ACYP3A4HRH4KDM4EALDH1A1 | |
| SCHEMBL13374043 | 0.83 | PRSS12 (0.41) | KMT2APRSS12HRH4CHEK1RAB9A | |
| SCHEMBL13375232 | 0.82 | PDPK1 (0.39) | KMT2ACHEK1KDM4ERAB9AALDH1A1 | |
| SCHEMBL3932241 | 0.82 | FGFR1 (0.42) | KMT2AHRH4KDM4EALDH1A1MAPT | |
| SCHEMBL3926103 | 0.82 | OPRL1 (0.42) | KMT2ACYP3A4ALDH1A1MAPTFLT3 | |
| SCHEMBL3926346 | 0.82 | CHEK2 (0.41) | KMT2AKDM4EFLT3 | |
| SCHEMBL13373939 | 0.82 | MAPT (0.46) | KMT2ACYP3A4PRSS12HRH4KDM4E | |
| SCHEMBL13374059 | 0.82 | KMT2A (0.39) | KMT2APRSS12HRH4KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |