Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | CLK3 | P49761 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13375051 | 0.94 | TUBB4A (0.40) | PDPK1JAK2TYK2CLK2CLK3 | |
| SCHEMBL13375042 | 0.89 | PDPK1 (0.39) | PDPK1JAK2TYK2CLK2CLK3 | |
| SCHEMBL6684006 | 0.85 | PDPK1 (0.43) | PDPK1JAK2TYK2CLK2CLK3 | |
| SCHEMBL13375123 | 0.83 | PDPK1 (0.46) | PDPK1JAK2TYK2CLK2CLK3 | |
| SCHEMBL13373930 | 0.83 | SYK (0.47) | PDPK1JAK2TYK2PARP1APAF1 | |
| SCHEMBL13375136 | 0.82 | KMT2A (0.37) | KDM4EALDH1A1HPGDKMT2ACHEK1 | |
| SCHEMBL13375137 | 0.82 | SYK (0.49) | DHODHKDM4EHPGDCHEK1RAB9A | |
| SCHEMBL13374055 | 0.82 | JAK2 (0.46) | PDPK1JAK2TYK2CLK2CLK3 | |
| SCHEMBL13375252 | 0.81 | AURKA (0.36) | PDPK1KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL13373895 | 0.81 | PDPK1 (0.45) | PDPK1JAK2TYK2CLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288425-B2 | Benzimidazoles | AVENTIS PHARMACEUTICALS INC. (US) | 2012-10-16 | — | — | US | disclosed |