Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.73 |
| ▸ | RAB9A | P51151 | 7/20 | 0.73 |
| ▸ | MEN1 | O00255 | 5/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.73 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.69 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | PLAU | P00749 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.62 |
| ▸ | CASP3 | P42574 | 2/20 | 0.62 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SMO | Q99835 | 1/20 | 0.58 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.58 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1335450 | 0.90 | KCNK9 (0.85) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL1337377 | 0.89 | KCNK9 (0.74) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL1335388 | 0.89 | RAB9A (0.70) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL8085694 | 0.88 | NPC1 (0.80) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL1336746 | 0.87 | TRPV1 (0.76) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL1336818 | 0.86 | KCNK3 (0.69) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL12129883 | 0.85 | SMO (0.78) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL1337518 | 0.84 | KCNK9 (0.84) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL30862297 | 0.81 | RXFP1 (0.94) | NPC1RAB9AMEN1KMT2AKCNK9 | |
| SCHEMBL4251968 | 0.81 | RXFP1 (0.94) | NPC1RAB9AMEN1KMT2AKCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | claimed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | claimed |
| US-9073835-B2 | N-acylthiourea and N-acylurea inhibitors of the Hedgehog protein signalling pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2015-07-07 | — | — | US | disclosed |
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275663-A1 | N-Acylthiourea and N-Acylurea Inhibitors of the Hedgehog Protein Signalling Pathway | SHH, GLI1, SMO | NPC1 857/4885RAB9A 1454/4885MEN1 3506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.