Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 12/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13375702 | 0.87 | MKNK1 (0.48) | MKNK1TRPV1 | |
| SCHEMBL13375706 | 0.87 | TRPV1 (0.52) | MKNK1TRPV1 | |
| SCHEMBL4206894 | 0.86 | TRPV1 (0.66) | MKNK1TRPV1 | |
| SCHEMBL4204231 | 0.85 | TRPV1 (0.56) | MKNK1TRPV1 | |
| SCHEMBL13375687 | 0.84 | MKNK1 (0.64) | MKNK1TRPV1 | |
| SCHEMBL13375703 | 0.83 | MKNK1 (0.46) | MKNK1TRPV1 | |
| SCHEMBL4202162 | 0.82 | TRPV1 (0.56) | MKNK1TRPV1 | |
| SCHEMBL4206710 | 0.81 | TRPV1 (0.54) | MKNK1TRPV1MAPTHPGDMAPK1 | |
| SCHEMBL13375725 | 0.80 | TRPV1 (0.54) | MKNK1TRPV1 | |
| SCHEMBL13375711 | 0.79 | MKNK1 (0.48) | MKNK1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288397-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-16 | — | — | US | disclosed |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | TRPV1, TRPA1, TRPV4 | MKNK1 874/4885TRPV1 1/4885MAPT 1073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.