Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 4/20 | 0.47 |
| ▸ | PARP1 | P09874 | 9/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13376141 | 1.00 | SERPINE1 (0.47) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL14028594 | 1.00 | SERPINE1 (0.47) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL2763287 | 1.00 | SERPINE1 (0.47) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL13911518 | 0.81 | SERPINE1 (0.40) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL14028585 | 0.81 | SERPINE1 (0.40) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL14028600 | 0.81 | SERPINE1 (0.40) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL2763503 | 0.81 | SERPINE1 (0.40) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL2763106 | 0.77 | GPR3 (0.47) | SERPINE1PARP1KDM4EALDH1A1TNKS | |
| SCHEMBL8907689 | 0.75 | SERPINE1 (0.36) | SERPINE1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL2763720 | 0.74 | SERPINE1 (0.35) | SERPINE1PARP1KDM4EALDH1A1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1420785-B1 | SUBSTITUTED INDENO [1,2-C]ISOQUINOLINE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2010-04-28 | — | — | EP | disclosed |