Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907884 | 0.79 | S100A4 (0.36) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8908307 | 0.77 | ACP3 (0.40) | KDM4EGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2763287 | 0.75 | SERPINE1 (0.47) | SERPINE1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL14028594 | 0.75 | SERPINE1 (0.47) | SERPINE1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL13376141 | 0.75 | SERPINE1 (0.47) | SERPINE1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL13377604 | 0.75 | SERPINE1 (0.47) | SERPINE1KDM4EALDH1A1MEN1MAPT | |
| SCHEMBL8907599 | 0.71 | CYP1A2 (0.38) | KDM4EPOLBRAB9APAX8ALDH1A1 | |
| SCHEMBL8908933 | 0.69 | HTR2C (0.40) | POLBALDH1A1CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL8908407 | 0.68 | ALDH1A1 (0.39) | POLBALDH1A1CYP2D6CYP3A4CYP2C9 | |
| SCHEMBL8908855 | 0.68 | CYP1A2 (0.44) | APAF1POLBRAB9AALDH1A1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | claimed |
| EP-0682657-A1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-11-22 | — | — | EP | claimed |
| WO-1994018175-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-08-18 | — | — | WO | claimed |
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | disclosed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | disclosed |
| EP-0682657-A1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-11-22 | — | — | EP | disclosed |
| US-5468748-A | Nervous system and psychological disorders; antagonize glycine binding site on N-methylaspartic acid receptor complex | NOVO NORDISK A/S (DK) | 1995-11-21 | — | — | US | disclosed |
| WO-1994018175-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-08-18 | — | — | WO | disclosed |